Unraveling cardiovascular disease: Genetic insights into atherosclerosis

Researchers at the School of Medicine, led by Mete Civelek, PhD, have made significant strides in understanding cardiovascular diseases like atherosclerosis, a leading cause of heart attacks and strokes. By studying the extracellular matrix secreted by smooth muscle cells, they identified genetic factors influencing plaque stability. Analysing proteins from 123 heart donors, they pinpointed 20 genomic locations linked to plaque composition. This research reveals a gene variant predisposing individuals to atherosclerosis and sheds light on protein types affecting cardiovascular risk. These insights could aid in identifying high-risk patients and developing targeted therapies. Notably, the identification of the LTBP1 protein’s role in plaque stability opens avenues for potential therapeutic targets. Published in Arteriosclerosis, Thrombosis, and Vascular Biology, this work was supported by various organisations, highlighting its significance in combating cardiovascular diseases.

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