The 5th Health Systems Innovation Hackathon, organised by the Harvard Health Systems Innovation Lab, is set for April 5th and 6th, 2024, with a focus on ‘Building High-Value Health Systems: Harnessing Digital Health and Artificial Intelligence.’ Featuring three tracks—Cardiovascular Disease and Diabetes, Cancer, and Mental Health—the event aims to gather global participants across various innovation hubs, including Boston, Buenos Aires, Kyiv, Lima, London, Santiago, and Sao Paulo. Anticipating hundreds of applicants, the hackathon serves as a platform to foster collaboration and innovation in leveraging digital health and AI to address critical healthcare challenges worldwide.